# Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV

> **NIH NIH R21** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2023 · $41,120

## Abstract

PROJECT SUMMARY/ABSTRACT
The purpose of this Diversity Supplement is to provide Mr. Jeremy Delgadillo, a Mexican American first-
generation college graduate and first-year PhD student, research experience and training to promote his
career development. This supplement will be nested in Dr. Pariya Wheeler’s R21 grant “Testing the Efficacy
and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV” (R21 AG076377-
01A1). The goal of the parent study is to test an adapted resilience intervention among 100 older PLHIV. This
proposal is particularly innovative due to its use of the real-time ESM approach to assess intervention efficacy
and mechanisms. Mr. Delgadillo will be positioned to leverage the rich baseline dataset from this parent
R21 study to examine several important temporal associations between stress reactivity, resilience
resources, and health outcomes among older PLWH. The baseline data collection will be complete within 1
year, allowing Mr. Delgadillo to engage in data analysis and dissemination in Year 2. Specifically, he will have
baseline data on 100 PLHIV, which includes an extensive assessment to measure sociodemographics and
stressful life events/trauma, health variables (e.g., comorbidities, HIV medical parameters), psychological
functioning, and HIV treatment management. Furthermore, the baseline data will also include a 14-day ESM
protocol that queries participants on stressful events, use of resilience resources, and affect. Importantly,
given the diverse sample of ~50% African American/Black PLHIV that will be enrolled in this R21, Mr.
Delgadillo will be well positioned to examine racial differences that may emerge in the findings, which
aligns with his interests in racial and health disparities. Together, this rich dataset will allow Mr. Delgadillo
to examine the following aims: AIM 1: To examine person-factors (e.g., race, SES, personality) as well as
factors related to lifetime stress (e.g., lifetime adversity and adverse childhood events) and momentary stress
(e.g., severity) as predictors of use of resilience resources (both global use and use of specific resources)
following stressors. AIM 2: To examine whether specific resilience resources better predict stress reactivity,
and whether resilience resources in turn predict better health outcomes (i.e., psychological functioning and HIV
outcomes). Impact: These research findings will fill a significant gap in the field on understanding how PLWH
react following stressors and how these behaviors impact health outcomes, which will inform the development
of both prevention and intervention strategies. Importantly, these results will supplement and complement the
results from the primary aims of the parent study that will assess intervention efficacy and mechanisms. The
research training and career development plan proposed by Mr. Delgadillo and his mentoring team will ensure
he is able to succeed in his future career, and will also prepare him to s...

## Key facts

- **NIH application ID:** 10702035
- **Project number:** 3R21AG076377-01A1S1
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Pariya Fazeli Wheeler
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $41,120
- **Award type:** 3
- **Project period:** 2022-08-15 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10702035

## Citation

> US National Institutes of Health, RePORTER application 10702035, Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV (3R21AG076377-01A1S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10702035. Licensed CC0.

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