# DPPOS AD/ADRD Health Economics Evaluation

> **NIH NIH U19** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 · $250,000

## Abstract

With this supplemental request, in DPPOS AD/ADRD during 2022-2027, we propose to extend our
previous analyses to evaluate the longer-term cost-utility and cost-effectiveness of the three original
DPP interventions by incorporating additional data on resource utilization, costs, health states/status,
health utilities, and mortality. To support these economic analyses, we will continue to collect
information on resource utilization and costs associated with the interventions and with medical care
outside the study, and information on health outcomes, health utilities, and survival. Based on the
resource utilization and cost data collected during DPP/DPPOS, we will summarize the total
healthcare costs associated with each of the three original DPP randomized interventions. As
recommended by the Second Panel on Cost-Effectiveness in Health and Medicine (3), healthcare costs
will include costs in the formal healthcare sector (e.g., costs associated with implementing and
maintaining the DPP/DPPOS interventions, and costs of medical care outside the study), those in the
informal healthcare sector (e.g., costs of time spent by participants on exercising and costs of time
spent by caregivers), and those in the non-healthcare sector (e.g., costs arising from lost productivity).
We will estimate the mean per capita healthcare costs associated with each of the three original DPP
randomized interventions over the time course of DPP/DPPOS, and calculate the incremental
healthcare costs of the ILS and MET interventions relative to placebo and each other from a
healthcare sector perspective and a societal perspective.

## Key facts

- **NIH application ID:** 10702144
- **Project number:** 3U19AG078558-01S1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Jose Alejandro Luchsinger
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $250,000
- **Award type:** 3
- **Project period:** 2022-09-01 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10702144

## Citation

> US National Institutes of Health, RePORTER application 10702144, DPPOS AD/ADRD Health Economics Evaluation (3U19AG078558-01S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10702144. Licensed CC0.

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