Title: Networking and Expanding Undergraduate Research On the Neurobiology of Aging to Advance Diversity (NEURON-Aging) ABSTRACT: The goal of this NIA R25 proposal “Networking and Expanding Undergraduate Research On the Neurobiology of Aging to Advance Diversity (NEURON-Aging)” is to expand the pool of researchers interested in biomedical, behavioral, and clinical aspects of brain aging and Alzheimer’s disease and related dementias (ADRDs) through undergraduate research activities that enhance diversity. Minority health disparities for cognitive outcomes in advanced age are well documented, with older adults from minority groups being more likely to self-report impairments and to develop dementia. Healthcare and research professions that are critical for addressing clinical needs in diverse elderly populations, however, have inadequate representation from diverse and disadvantaged groups. This is a significant barrier for mitigating these health inequities. Thus, there is an urgent and unmet need to support educational pipeline programs that increase the diversity of the research and clinical workforce focused on understanding and treating brain aging and ADRD to reduce minority health disparities. The current proposal will expand the pool of undergraduate trainees interested in pursuing research and clinical careers related to understanding and treating brain aging and ADRD with 3 Specific Aims. Aim 1 will increase the participation of University of Florida (UF) underrepresented minority (URM) undergraduate students conducting mentored research on the neurobiology of aging and ADRDs in NIH-funded laboratories and expand their research network to facilitate an interest in brain aging. Aim 2 will increase the representation of URM undergraduates from outside UF and non-Research I Institutions conducting mentored research in NIH-funded laboratories examining brain aging and ADRDs. Finally, using institutional matching funds provided by Centers and Institutes at the University of Florida, Aim 3 will increase the numbers of diverse students proceeding on to top graduate programs focused on brain aging by proving 12-24 months of postbaccalaureate training as a bridge to PhD training. The proposed education and research training program will have the following measurable objectives: (1) NEURON-Aging students will develop an appreciation for brain aging and related diseases through year-round mentorship and networking; (2) NEURON-Aging students will have an increased sense of scientific efficacy through mentored, hands-on research training; 3) NEURON-Aging students will have an enhanced understanding of experimental design and data interpretation in brain aging-research areas, (4) NEURON-Aging students will develop professional communication skills by presenting their research locally and nationally; (5) NEURON-Aging students will develop awareness of graduate and professional school program application processes; and (6) The majority (>50%) of NEURON-A...