Project Summary/Abstract: The main goal of the BAATAAR-UP ARTNet Admin Core is to ensure regular communication between the leaders and teams involved in Project 1 led by Dr. Bivona and Dr. Blakely (Clinical tumor-TME acquired resistance), Project 2 led by Dr. Roth and Dr. Bivona (PDX tumor-TME acquired resistance), Project 3 led by Dr. Bandyopadhyay and Dr. Kuo (PDO tumor- TME acquired resistance), and the Data Science Core, led by Dr. Wang and Dr. Bandyopadhyay. Additional goals include ensuring regular communication with the NCI, and other ARTNet centers as well as with the basic, translational, and clinical scientific stakeholders, and with lung cancer advocacy groups and the public at large. These goals will be accomplished through three specific aims. The first aim will be to effectively manage and integrate scientific projects and budgets. The Admin Core will create a Leadership Team consisting of the Project and Data Science Core Leads, which will evaluate the progress and impact of research accomplished through regular monthly team meetings as well as an annual retreat. The Admin Core will also oversee the submission of scientific progress reports to the NCI in collaboration with the Leadership Team. The second aim of the Admin Core will be to organize intra and trans-institutional activities to ensure regular communication between the project teams with each other and with the Data Sciences Core. The Admin Core will ensure resource and data sharing between each Project and with the Data Science Core. The Admin Core will also ensure regular communication between the Leadership Team and the Scientific Advisory Board (SAB), as well as the broader scientific and patients advocacy community. This will be accomplished by organizing an annual research retreat in which project teams will present research progress and receive feedback and guidance from the SAB. The SAB will include a range of experts with extensive knowledge of EGFR and KRAS biology and acquired resistance to molecular targeted therapies as well as clinical and patient expertise. The Admin Core will also ensure regular presentation of our findings by coordinating travel and presentations at scientific conferences. Finally, the Admin Core will ensure engagement with patient advocacy groups and the general lay community. In these events, our scientific team will communicate our research to a diverse lay audience, as well as seek input and observations from the community for our work. The third aim of the Admin Core is to organize interactions with the NCI and other national ARTNet Centers. The Admin Core will spearhead coordination and communication directly with the ARTNet Coordinating and Data Management Center (CDMC) and NCI scientific staff, as well as coordinate teleconferences with other ARTNet centers and/or the NCI scientific staff to communicate updates on the progress of the Research Program and enhance the strength of interpersonal interactions among all ARTNet stakehold...