PROJECT SUMMARY (Biospecimen and Pathology Core) The translational research proposed in the MD Anderson Cancer Center Prostate Cancer SPORE requires a broad range of comprehensive support. The Biospecimen and Pathology Core supports investigators by providing (1) a biospecimen resource with clinically and pathologically annotated biospecimens that encompass the clinical spectrum of prostate cancer; (2) clinically relevant patient-derived xenografts reflective of the clinical challenges addressed in the projects; (3) clinical and laboratory personnel experienced in the conduct, collection, and processing of specimens from clinical trials; and (4) dedicated pathologists and clinicians with technical expertise who will conduct and interpret tissue-based studies and coordinate all core activities. To maximize analyses using small samples and enhance collaboration among investigators at MD Anderson and other institutions, Core personnel will prepare and distribute tissue derivatives linked with specific disease states. Close collaboration with investigators and electronic processing of requests for biospecimens and clinical information by the Tissue Acquisition and Distribution Committee will ensure the evolving needs of each project will be met in a timely manner. In addition, the Core’s Prometheus informatics staff will manage the repository for clinical and translational data so that investigators will have the full power of detailed, well-curated clinical annotations essential to maximizing the information gained from often small samples. The Prometheus system also facilitates the interpretation of analyses within specific clinical and biologic contexts and enhances interactions among projects. Other functions of Prometheus are to ensure common data format and ontologic term usage, data integrity, audit history, and data security. Prometheus will also facilitate future data exchanges with investigators and SPOREs at other institutions. Finally, Prometheus will enable all statistical analyses performed in the Biostatistics and Bioinformatics Core to be carried out using the most up-to-date clinical and translational data.