Core A, the Administrative Core of Mayo Clinic’s Hepatobiliary Cancer SPORE, will provide an overall organizational infrastructure to encourage collaboration, manage finances, and coordinate the review of progress of the research projects, scientific cores and developmental programs (Developmental Research Program and Career Enhancement Program). The Administrative Core will also ensure optimal function of all SPORE components and encourage communication between the SPORE, Mayo Clinic Cancer Center, Mayo Clinic as a whole, other Hepatobiliary SPOREs, other Mayo SPOREs, SPORE collaborations with non-SPORE funding instruments, and the National Cancer Institute. In addition, the Administrative Core will consult with the members of the SPORE committees including the External and Internal Advisory boards in order to achieve maximum potential for translational objectives. Core A’s specific aims are to: 1) Provide leadership and collaboration between the Research Projects and Cores of the SPORE; 2) Assure incorporation and participation of the Hepatobiliary Cancer SPORE in the activities of Mayo Clinic Cancer Center; 3) Establish monthly meetings of SPORE investigators and the Internal Advisory Board; 4) Arrange yearly research retreats and 2x/year meetings of the External Advisory Board; 5) Coordinate meetings of the Mayo Clinic Cancer Center SPORE Directors’ Working Group as needed; 6) Provide administrative support to the Developmental Research Program and to the Career Enhancement Program; 7) Facilitate investigator trips to relevant SPORE meetings; 8) Enable activities of the Hepatobiliary Cancer SPORE advocates; 9) Prepare the yearly non-competing SPORE application; 10) Serve as the administrative liaison between the Mayo Clinic SPORE and the NCI SPORE Program, other SPOREs, and collateral organizations; 11) Maintain the Mayo Hepatobiliary Cancer SPORE Websites that will be useful to investigators inside and outside the SPORE, as well as patients; 12) Coordinate information and communication about SPORE research developments to the Mayo Clinic SPORE investigators, the scientific community at large, and the public.