# Hemorrhage and Thrombosis in Extracorporeal Life Support

> **NIH NIH P20** · OCEAN STATE RESEARCH INSTITUTE, INC. · 2022 · $179,544

## Abstract

Extracorporeal life support (ECLS) rescues critically ill patients with refractory cardiopulmonary failure. 
Hemorrhage and thrombosis are the most significant causes of morbidity and mortality in ECLS; stroke and 
intracerebral hemorrhage (ICH) are the most devastating among them. The use of ECLS has exploded, 
however studies to date have been unable to predict these complications. Amyloid beta (Al3) plays a central 
role in cerebral hemostasis and may contribute to neurologic complications during ECLS. Cerebral oximetry 
via near-infrared spectroscopy (NIRS) can detect cerebral ischemia. The long-term goal of the Pl's 
research is to harness rigorous bioinformatic techniques to identify and validate novel markers of 
hemorrhage and thrombosis in ECLS to improve outcomes. The Pl's central hypothesis is that machine 
learning will identify key and modifiable risk factors for bleeding and thrombosis and that incorporating 
innovative neurophenotyping (Al3 levels and NIRS) will enhance network prediction for neurological 
complications. The Pl will test this hypothesis by pursuing the following three aims: 
Aim 1: Generate and cross-validate machine learning models to predict hemorrhage (including 
ICH) within ELSO and collaborative datasets 
Aim 2: Generate and cross-validate machine learning models to predict thrombosis (including 
ischemic stroke) within ELSO and collaborative datasets 
Hypothesis: Novel networks of patient-, clinical-, and time-based factors will emerge as strong predictors 
of hemorrhage (Aim 1), and thrombosis (Aim 2), respectively.

## Key facts

- **NIH application ID:** 10708435
- **Project number:** 5P20GM103652-10
- **Recipient organization:** OCEAN STATE RESEARCH INSTITUTE, INC.
- **Principal Investigator:** Adeel Abbasi
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $179,544
- **Award type:** 5
- **Project period:** 2022-06-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10708435

## Citation

> US National Institutes of Health, RePORTER application 10708435, Hemorrhage and Thrombosis in Extracorporeal Life Support (5P20GM103652-10). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10708435. Licensed CC0.

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