# MorPhiC Data Resource and Administrative Coordinating Center

> **NIH NIH U24** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2023 · $1,474,991

## Abstract

PROJECT SUMMARY
Since the successful conclusion of the Human Genome Project (HGP), significant progress has been made
towards the NHGRI strategic vision to characterize the biological function(s) of every human gene. A systematic
catalogue of molecular and cellular phenotypic effects of gene knockouts for all human genes in complex cell-
based model systems would fill a current gap between direct molecular readouts such as gene expression and
whole model organism phenotypes. It would provide another critical tool to characterize the biological functions
of all genes towards the strategic vision. The pilot phase of the Molecular and Cellular Phenotypes of Null Alleles
in Cells (MorPhiC) program will study the feasibility, scalability, required scope, and utility of such a catalogue to
characterize phenotypes associated with genes in tissue- and disease-relevant human cellular model systems.
The proposed MorPhiC Data Resource and Administrative Coordinating Center (DRACC) will enable and
support the MorPhiC research consortium by providing the highest quality FAIR (findable, accessible,
interoperable, reusable) MorPhiC data resource, analyzing, annotating, and disseminating Morphic data,
integrating external data/information, and serving as an administrative and coordination center. These functions
will be fulfilled in close cooperation and collaborating with the Data Production Research and Development
Centers (DPCs) and the Data Analysis and Validation Centers (DAVs) to support rigorous data standards, rich
metadata annotations, the highest data and software quality, and reproducibility and portability of data
processing and -analysis tools.
Members of our team have previously served in leadership positions of several national and international
research consortia, including the Human Cell Atlas (HCA), Knockout Mouse Program (KOMP), Genome-Wide
Association Studies (GWAS) Catalog, Library of Integrated Network-based Cellular Signatures (LINCS),
Illuminating the Druggable Genome (IDG), Big Data to Knowledge (BD2K), and Monarch Initiative. Our team has
the technological, scientific, and administrative expertise to successfully operate the Center and complete the
Center and Consortium critical functions and deliverables via Specific Aims to 1) Establish and operate the
Center, 2) Deploy a state-of-the-art infrastructure to manage data across the entire life cycle, 3) Collate,
converge, and deploy cloud-enabled analysis techniques, models and data processing protocols, 4)
Create and deploy the MorPhiC Web Portal to provide global access to MorPhiC data, 5) Map and
integrate external data sources, and 6) Administer and coordinate the Consortium.
Successful completion of these Aims will enable the assessment of feasibility, scalability, required scope, and
utility of a MorPhiC Catalogue with the prospect to massively scale the functional characterization of every human
gene via phenotype mapping in relevant human model systems.

## Key facts

- **NIH application ID:** 10709019
- **Project number:** 5U24HG012674-02
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** Anthony John Charles Burdett
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,474,991
- **Award type:** 5
- **Project period:** 2022-09-22 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10709019

## Citation

> US National Institutes of Health, RePORTER application 10709019, MorPhiC Data Resource and Administrative Coordinating Center (5U24HG012674-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10709019. Licensed CC0.

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