# University of Washington Center of Excellence in Opioid Addiction Research

> **NIH NIH P30** · UNIVERSITY OF WASHINGTON · 2024 · $1,599,427

## Abstract

Overall Project Summary
The “University of Washington Center of Excellence in Opioid Addiction Research” is designed to provide shared
resources that would continue to enhance efficiency and facilitate collaborative research for the study of the
effects of opioids on neural circuits with the goal of understanding opioid addiction mechanisms and developing
novel treatments for drug addiction. Center participants from 27 University of Washington laboratories are using
optogenetic control of rodent behavior, in vivo neuroimaging of single cell calcium signals and other receptor
signaling probes, viral gene expression, and CRISPR/cas9 manipulations to deconstruct and study opioid
addiction mechanisms. This group has a long history of highly productive, collaborative, cutting-edge research
and training that will be strengthened by the continued sharing of resources provided by this award. The renewed
NIDA-P30 Center would continue to be comprised of four components: The Administrative Core will coordinate
resource utilization, organize weekly Research Progress Meetings, organize training, professional development
of trainees, and URM outreach efforts. The Imaging and Neural Circuits Core would develop and maintain
shared resources for in vivo brain imaging in rodents using 1-Photon endoscopy, Inscopix imaging, 2-Photon
confocal microscopy, Spatial Light Modulation, fiber photometry, Neuropixels in vivo electrophysiology, and
operant behaviors. The Molecular Genetics Resource Core would provide DIO-AAV / CRISPR-cas9 / Canine
Adeno Viral reagents, develop new activity actuators and novel sensors, and would provide advanced training
in cell-specific genetic manipulation coupled with behavioral and computational analysis. A Pilot Project Core
would enable NIDA-P30 faculty participants and trainees to initiate new projects utilizing the Imaging and Genetic
Cores and would foster training and collaborations within the NIDA-P30 Center laboratory groups and the
university community at large. The NIDA-P30 Center would continue as a national neuroscience resource by
providing training to visiting scientists, reagents for genetic manipulation, and novel actuators/sensors on request
from investigators at other institutions. The NIDA-P30 Center will support the recruitment and professional
development of early-stage investigators and URM/1st Gen trainees both at the University of Washington and
through active collaborations with HBCU Institutions. It will provide workshops and summer courses for training
advanced undergraduate and graduate students in optogenetics, computational neuroscience, and viral design
& construction techniques. All of these components would be focused on understanding the changes in neural
circuitry responsible for opioid addiction and on the development of new therapeutic tools for translation based
on these insights.

## Key facts

- **NIH application ID:** 10711358
- **Project number:** 2P30DA048736-06
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Charles Chavkin
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,599,427
- **Award type:** 2
- **Project period:** 2019-07-01 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10711358

## Citation

> US National Institutes of Health, RePORTER application 10711358, University of Washington Center of Excellence in Opioid Addiction Research (2P30DA048736-06). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10711358. Licensed CC0.

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