Pediatric Malignancies Program: Summary/Abstract Pediatric malignancies encompass a range of tumor types, and HDFCCC Pediatric Malignancy (PE) Program members are focused on diverse cancers, including leukemias, brain tumors, and sarcoma. Many of these are embryonal tumors, cancers that begin in embryonic tissues and that often represent failure of normal differentiation. The goal of the PE Program is to advance the development of new therapies for pediatric cancer by enabling basic, translational, and clinical research with the goal of developing new effective targeted therapies for children with minimal toxicities. Specifically, PE member research focuses on (1) discovering and validating novel therapeutic targets for pediatric cancers; (2) clinically advancing new therapeutic strategies to improve outcomes for pediatric cancer patients; and (3) understanding the link between cancer and normal human development.