# CHEMICAL SYNTHESIS FACILITY

> **NIH NIH N01** · UNIVERSITY OF MINNESOTA · 2022 · $750,946

## Abstract

The Contraceptive Development Program (CDP) supports research in the synthesis and testing of a broad spectrum of male and female contraceptive agents. Successful development of new contraceptive methods for men and women has been a goal for many decades. From the inception of this program, the CDP has had a continuing need for a Chemical Synthesis Facility (CSF) capable of synthesizing potential anti-fertility agents on a laboratory milligram to gram scale to a relatively
larger kilogram scale. The kilogram scale chemical agents are manufactured under current Good Manufacturing Practices (cGMP) for comprehensive contraceptive evaluation, including toxicology studies and preclinical safety studies before entering human clinical studies.
The CSF provides the Government with chemicals, chemical intermediates, steroids, drug candidates, and drugs, which are either a new chemical entity (NCE) commercially unavailable or unduly expensive to obtain commercially. The areas of chemical synthesis for CSF consist of small molecule antagonists or agonists of protein targets, including but not limited to active natural products, natural product analogues, active steroids estrogens, progestins, androgens, and their analogues. In addition, CSF has an important role in support of providing intermediates for the
synthesis of many unnatural amino acids that may be incorporated into the preparation of unnatural peptide agonists or antagonists by another CDP's contractor.

## Key facts

- **NIH application ID:** 10713604
- **Project number:** 75N94022C00005-0-9999-1
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** VADIM GURVICH
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $750,946
- **Award type:** —
- **Project period:** 2022-09-29 → 2023-09-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10713604

## Citation

> US National Institutes of Health, RePORTER application 10713604, CHEMICAL SYNTHESIS FACILITY (75N94022C00005-0-9999-1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10713604. Licensed CC0.

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