# Neural circuits for social modulation of a persistent negative emotional state > **NIH NIH RF1** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2023 · $3,241,005 ## Abstract PROJECT SUMMARY In social species, social relationships can exert profound influences on individuals’ behavioral and physiological states. In particular, social interactions can help reduce negative emotional state induced by physical or psychological stressors, a phenomenon known as social buffering. Social buffering provides an important means by which the social environment facilitates stress coping and resilience and benefits health and well-being. Despite the conservation of social buffering in a wide range of species from rodents to humans, how incoming social information modulates stress-related neural activity to mitigate stress responses remains poorly understood. A better grasp of the neural circuitry underlying social buffering will provide critical insights into principles governing the intricate interaction between social experience and emotional state. Conceptually, the long-lasting negative emotional state that often ensues from acute stress exposure is likely underpinned by persistent changes in neural states in stress-related brain areas. Supporting this notion, the Zhang lab recently showed that this long-lasting negative emotional state is represented and controlled by a persistent increase of neural activity in glutamatergic (Vglut2) neurons in the medial preoptic area (MPOA) (Zhang 2021). Interestingly, recent work from the Hong lab found that GABAergic (Vgat) neurons in the medial amygdala (MeA), a key node in social information processing, mediates positive valence associated with social interactions and acutely suppresses anxiety-like behavior through the projections of these neurons to the MPOA (Hu 2021). These findings led us to propose a conceptual model for social buffering in which social interactions mitigate stressor-induced negative state by attenuating persistent neural activity that maintains this state. We hypothesize that activation of MeA GABAergic neurons during social interactions leads to enhanced inhibitory input into MPOA glutamatergic neurons, resulting in a long-lasting suppression of their persistent activity and a consequent amelioration of stressor-induced negative emotional state. Our collaborative team will combine in vivo calcium imaging, electrophysiological recording, functional manipulation, and computational modeling to address a series of important questions: (1) How is stressor-induced persistent activity in MPOA Vglut2 neurons modulated by social interaction (Aim 1)? (2) Do social signals from MeA Vgat neurons drive activity changes in MPOA Vglut2 neurons and is this modulation functionally important for social buffering (Aim 2)? (3) How is social modulation of persistent neural activity in MPOA Vglut2 neurons relayed to downstream circuits to mediate social buffering (Aim 3)? (4) Can computational models that incorporate different cellular/synaptic mechanisms explain stress-induced activity dynamics and its social modulation in MPOA Vglut2 neurons and downstream circuits (Aims 1–3)? Colle... ## Key facts - **NIH application ID:** 10721276 - **Project number:** 1RF1NS132912-01 - **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES - **Principal Investigator:** Weizhe Hong - **Activity code:** RF1 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2023 - **Award amount:** $3,241,005 - **Award type:** 1 - **Project period:** 2023-09-01 → 2026-08-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10721276 ## Citation > US National Institutes of Health, RePORTER application 10721276, Neural circuits for social modulation of a persistent negative emotional state (1RF1NS132912-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10721276. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*