# Defining renal S1P/sPRR/AT1R pathway  in salt-sensitive hypertension

> **NIH VA I01** · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2024 · —

## Abstract

The important role of renin-angiotensin-aldosterone system in the pathogenesis of
hypertension is highlighted by the wide use of its inhibitors for treatment of hypertension.
The current proposal will address the role of renal site-1 protease/soluble (pro)renin
receptor in pathogenesis of salt-sensitive hypertension. The proposal has the potential to
advance our understanding of the fundamental mechanism of hypertension and also to
identify a novel target for antihypertensive therapies.

## Key facts

- **NIH application ID:** 10725141
- **Project number:** 5I01BX004871-04
- **Recipient organization:** VA SALT LAKE CITY HEALTHCARE SYSTEM
- **Principal Investigator:** Tianxin Yang
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2024
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2020-10-01 → 2024-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10725141

## Citation

> US National Institutes of Health, RePORTER application 10725141, Defining renal S1P/sPRR/AT1R pathway  in salt-sensitive hypertension (5I01BX004871-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10725141. Licensed CC0.

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