# P21-activated kinase 1 is a novel regulator of cardiac and adipose tissue function in females

> **NIH NIH K01** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2023 · $54,000

## Abstract

Project Summary
Experiments proposed in this K01 aim to investigate a novel role of PAK1 in the regulation of cardiac
function and adipose tissue homeostasis in female mice. The specific aims are: Aim #1 To investigate the
mechanisms by which estrogens regulate PAK1 in the heart and adipose tissue. Aim #2: To investigate
the mechanisms by which PAK1 regulates cardiac function in female mice. Aim #3: To investigate the
mechanisms by which PAK1 regulates adipose tissue homeostasis in female mice and the effect of its
dysregulation on cardiac function. The scope of the research planned for this supplement is to study the
effects of FTY720 (fingolimod) in a model of heart failure linked to obesity and hypertension.

## Key facts

- **NIH application ID:** 10725342
- **Project number:** 3K01HL155241-02S1
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** Paola Cecilia Rosas
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $54,000
- **Award type:** 3
- **Project period:** 2021-08-16 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10725342

## Citation

> US National Institutes of Health, RePORTER application 10725342, P21-activated kinase 1 is a novel regulator of cardiac and adipose tissue function in females (3K01HL155241-02S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10725342. Licensed CC0.

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