# Preliminary Functional Studies of an Understudied NDD Gene in Mice

> **NIH NIH R03** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2023 · $148,500

## Abstract

Project Summary/Abstract
Neurodevelopmental disorders are common, debilitating disorders including autism, intellectual disability, and
perhaps even schizophrenia. Recent genetic findings have identified mutations in multiple genes in various
cellular pathways as genetic causes of rare neurodevelopmental disorders including autism spectrum
disorders, intellectual disability, and others. This proposal will characterize a novel genetic mouse model,
already generated by our laboratory and breeding in our laboratory, to delineate the function of a relatively
understudied disease gene in the brain. Specifically, the proposal will be on a gene implicated in a well-defined
neurodevelopmental disorder. We propose to obtain preliminary behavioral data in this mouse model on
multiple ID-related, ASD-related, and control behavioral tasks. In parallel, we will obtain preliminary single
nucleus RNA-seq transcriptomics data and perform preliminary analyses while also examining a specific
chromatin modification that we predict will be altered in the genetic mutant mouse model. These unbiased,
preliminary, experiments will identify novel downstream targets in mammalian brain, elucidate behavioral
outcome measures for future studies, and generate new hypotheses anticipated to lead to future potential
therapeutic strategies.

## Key facts

- **NIH application ID:** 10726239
- **Project number:** 1R03MH133908-01
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Craig M Powell
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $148,500
- **Award type:** 1
- **Project period:** 2023-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10726239

## Citation

> US National Institutes of Health, RePORTER application 10726239, Preliminary Functional Studies of an Understudied NDD Gene in Mice (1R03MH133908-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10726239. Licensed CC0.

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