# Dynamic regulation of neuroinflammation and IL-1b-trap

> **NIH NIH R21** · FLORIDA ATLANTIC UNIVERSITY · 2023 · $419,375

## Abstract

PROJECT SUMMARY
IL-1 is a master neuroimmune regulator. IL-1 activity is important for both physiological functions
of the brain and pathogenesis of all CNS diseases. The cellular sources of IL-1 are not well
defined and genetic access to manipulating IL-1-expressing cells is lacking. We have created
an IL-1-trap mouse to visualize IL-1 expressing cells. In addition, we can inhibit or activate IL-
1-expressing cells by chemogenetic methods. Using this new tool, we will: 1) demonstrate
distinct sets of cells express IL-1 in homeostasis and in different neuroimmune activation
conditions; 2) determine the role of homeostatic IL-1-expressing cells on the neurochemical and
behavioral consequences following peripheral and central inflammatory challenge; and 3)
determine the role of the induced IL-1-expressing cells on the neurochemical and behavioral
consequences following peripheral and central inflammatory challenges.

## Key facts

- **NIH application ID:** 10726269
- **Project number:** 1R21NS133843-01
- **Recipient organization:** FLORIDA ATLANTIC UNIVERSITY
- **Principal Investigator:** Ning Quan
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $419,375
- **Award type:** 1
- **Project period:** 2023-06-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10726269

## Citation

> US National Institutes of Health, RePORTER application 10726269, Dynamic regulation of neuroinflammation and IL-1b-trap (1R21NS133843-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10726269. Licensed CC0.

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