# A fully implantable speech neuroprosthesis

> **NIH NIH UG3** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $1,526,494

## Abstract

Loss of communication is one of the most devastating consequences of severe paralysis from a range of disorders, including ALS, stroke, and muscular dystrophy. Recent and ongoing studies have demonstrated the ability to decode words and sentences directly from the neural activity of a paralyzed individual who cannot speak. This success highlights the feasibility of synthesized speech decoded from neural signals using electrocorticography and lays critical groundwork for the development of a fully implantable speech prosthesis. A total implantable device will eliminate physical tethering, reduce infection risk, enable mobile, on-the-go use, expand communication training and capability, and improve patient autonomy and quality of life. Accordingly, we propose to finalize the development of a fully implantable speech prosthesis device system designed to restore real-time communication for patients suffering from severe dysarthria or anarthria. The system features a wireless brain interface device for ECoG recording, digitalization and data streaming and an external portable computer receiving data and hosting real-time speech decoding algorithms. Here, we will complete development and testing of the 3D electronic packaging, the electrode array, and peripherals to enable full integration of the device; undertake device manufacturing and perform functional and safety testing; obtain an FDA IDE; and perform intra-operative clinical studies to optimize the electrode interface and verify critical aspects of device performance. These studies will provide critical groundwork for future chronic implantation trials and subsequent commercialization.

## Key facts

- **NIH application ID:** 10728678
- **Project number:** 1UG3NS130527-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Edward Chang
- **Activity code:** UG3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,526,494
- **Award type:** 1
- **Project period:** 2024-02-05 → 2026-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10728678

## Citation

> US National Institutes of Health, RePORTER application 10728678, A fully implantable speech neuroprosthesis (1UG3NS130527-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10728678. Licensed CC0.

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