SUMMARY: DATA INTEGRATION AND COMPUTATION CORE A major challenge to any integrated, collaborative, multi-institutional effort is the centralized management and synthesis of shared data. The Data Integration and Computation Core will be central to every part of our Mayo/Columbia CSBC Mathematical Oncology Systems Analysis Imaging Center (MOSAIC), assimilating diverse data types and sources. The primary mission of this Core is to provide infrastructure for data resource management, including modeling tools and support. The Data Integration Core will house and integrate the digital data generated by the Biospecimen Core while providing a central resource for modeling tools to support our CSBC and interacting with the Administration Core for ensuring IRB compliance. We will achieve the mission of our Data Integration and Computation Core through three specific aims. In Aim 1 we collect and process and store data across all CSBC sites. In Aim 2 we provide and integrate reproducible bioinformatics workflows. And in Aim 3 we provide computational modeling tools and techniques. The Data Integration Core will provide support for both projects. • Project 1: Targeting Glioma Tissue States will utilize the image-localized biopsy locations. They will further utilize the stored molecular data accessed through this core making use of the provided bioinformatics. • Project 2: Imaging the Dynamic Tissue State in Patients In Vivo will utilize the stored molecular and imaging data along with all segmentations and generated image features. Project 2 will also make extensive use of the mechanistic modeling and calibration support along with the bioinformatics support.