# Investigating Environmental Microplastic Particles and Pollutant Interactions in a Changing Environment

> **NIH NIH P01** · UNIVERSITY OF ROCHESTER · 2024 · $218,694

## Abstract

Abstract – Project 2 
The objectives of Project #2 are to improve our understanding of human exposure to environmental microplastics 
and to learn how persistent organic pollutants (POPs) and metal ions interact with microplastics to modify toxicity. 
Microplastics are ubiquitous environmental pollutants. Though humans are chronically exposed to microplastics, 
the literature pertaining to mammalian health risks is sparse. The preponderance of literature focuses on 
enumerating the size, shape and color of environmental microplastics and on examining the toxicity of 
commercial pure plastic particles, principally polystyrene microspheres, on aquatic organisms. Studies find that 
microplastic toxicity increases with decreasing microplastic size, however, collecting environmental microplastic 
<100 ìm in diameter for testing is challenging, so it is rarely done. Recently, we showed that nanomembrane 
filter technology is able to filter microplastics in size ranges that are smaller than is typically feasible and is more 
likely to breech epithelial barriers to interact directly with cells. Furthermore, it is known that environmental 
microplastics adsorb POPs and/or metal pollutants, yet little is fundamentally understood about how 
microplastic/pollutant interactions may alter toxicity. This project seeks to remedy these knowledge gaps by 
enumerating the presence of microplastics <100 ìm in diameter in Lake Ontario water and in airborne Lake 
spray and testing the microplastic enriched in the retentate for cytotoxicity/bioactivity including aryl hydrocarbon 
receptor activity and endocrine disrupting properties. We will investigate microplastic interactions with POPs 
and metals that are abundant in Lake Ontario as a function of temperature to account for seasonal variations. 
The overall hypothesis of this project is that filtered debris from Lake Ontario water and airborne Lake spray 
will exhibit biological activity and that pollutant-MP interactions will alter bioactivity depending on MP 
composition and temperature.

## Key facts

- **NIH application ID:** 10732587
- **Project number:** 1P01ES035526-01
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **Principal Investigator:** Lisa A DeLouise
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $218,694
- **Award type:** 1
- **Project period:** 2024-03-11 → 2029-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10732587

## Citation

> US National Institutes of Health, RePORTER application 10732587, Investigating Environmental Microplastic Particles and Pollutant Interactions in a Changing Environment (1P01ES035526-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10732587. Licensed CC0.

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