# Pilot Projects and Trans-Network Activities

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2023 · $3,366

## Abstract

PILOT PROJECTS AND TRANS-NETWORK ACTIVITIES CORE
University of California and UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development
and Trial Center (UCaTS) to Reduce Cancer Health Disparities
PROJECT SUMMARY/ABSTRACT
The goal of the Pilot Projects and Trans-Network Activities Core (PPTNAC) is to contribute to the achievement
of the University of Californiaand UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and
Trial Center (UCaTS) overall objectives of developing PDX trial strategies for preclinical testing of single agents
and drug combinations. This D-PDTC focuses on the predominant racial/ethnic minority populations residing in
California and Texas, namely, Latinos, African American [AAs] and Asian American/Native Hawaiian/Pacific
Islander [AANHPIs]. The focus will be on gastric cancer which disproportionately affect Latinos and all
populations of color, and lung cancer, which has a high burden in Latino and AANHPI women. Key personnel
for this Core include the PPTNAC Lead Moon S. Chen, Jr., who has successfully led PPTNAC in our ongoing
UCaMP PDX Development and Trial Center (PDTC), all Site PIs, Contact PI and Administrative Core Lead Luis
Carvajal-Carmona, and UCaTS Grant Administrator. As such, PPTNAC investigators reflect multiple relevant
disciplines that foster the evaluation of pilot studies and trans-network activities including cancer health
disparities, pre-clinical studies, pathology, and basic cancer research. PPTNAC will also facilitate the interaction
of UCaTS with NCI, PDXNet Data Commons and Coordinating Centers (PDCCC), other PDTCs, and non-
PDXNet investigators through funded projects. Specifically, the PPTNAC Aims are to: (1) Facilitate Internal Pilot
Projects; (2) Facilitate Cross-PDXNet Activities (Pilot Studies Development and Evaluation); and (3) Engage
Non-Network Investigators; and (4) Share Innovative Technologies using PDXs (Collaboration with non-PDXNet
investigators).

## Key facts

- **NIH application ID:** 10733397
- **Project number:** 1U54CA283766-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Moon Shao-Chuang Chen
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $3,366
- **Award type:** 1
- **Project period:** 2023-08-01 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10733397

## Citation

> US National Institutes of Health, RePORTER application 10733397, Pilot Projects and Trans-Network Activities (1U54CA283766-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10733397. Licensed CC0.

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