# Toxicity of saxitoxin congener mixtures in shellfish from Southeast Alaska

> **NIH NIH P01** · SITKA TRIBE OF ALASKA · 2024 · $94,104

## Abstract

PROJECT SUMMARY / ABSTRACT
Project 2 of the Knowledge Warding Against Toxin Levels Center will be co-led by Kari Lanphier, head of the
Southeast Alaska Tribal Ocean Research Consortium, and Dr. Thomas Webster, an environmental health
academic expert on chemical mixtures. The purpose of Project 2 is to evaluate different estimates of the
toxicity of the saxitoxin congeners in shellfish. Specifically, Project 2 will (1) Compare predictions of shellfish
saxitoxin-related toxicity using a bioassay (RBA) measuring total toxicity with estimates based on
measurement of individual saxitoxin congeners (via HPLC) plus Toxic Equivalency Factors (TEF) from
FAO/WHO; (2) test whether saxitoxin congeners adequately predict RBA using the TEF model; and (3)
improve TEF estimates by regressing RBA against saxitoxin congener concentrations using new mixtures
methods.

## Key facts

- **NIH application ID:** 10733892
- **Project number:** 1P01ES035551-01
- **Recipient organization:** SITKA TRIBE OF ALASKA
- **Principal Investigator:** Thomas F Webster
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $94,104
- **Award type:** 1
- **Project period:** 2024-03-20 → 2029-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10733892

## Citation

> US National Institutes of Health, RePORTER application 10733892, Toxicity of saxitoxin congener mixtures in shellfish from Southeast Alaska (1P01ES035551-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10733892. Licensed CC0.

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