# Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $3,222,420

## Abstract

Project Summary/Abstract of CARE 2.0
 Despite being the fastest growing racial population in the United States, Asian American,
Native Hawaiian, and Pacific Islander (AANHPI) persons remain severely underrepresented in
research. For example, less than 3% of participants in the National Alzheimer's Coordinating
Center database are AANHPI individuals and even fewer are enrolled in clinical trials of
promising therapeutics. The Collaborative Approach for Research and Education (CARE)
registry (R24 AG063718) is a US multi-lingual registry built to improve AANHPI representation
in Alzheimer’s disease and related dementias (ADRD), aging, and caregiving research.
Launched in October 2020, CARE has enrolled 9,405 AANHPI adults (as of 10/2/22) including
55.9% with limited English proficiency and 80.9% with no prior research participation
experience. CARE has referred more than >5,500 participants to 27 studies that are in various
stages of recruitment and study completion. As a critical next step and guided by the NIA health
disparities framework, we propose CARE 2.0 to strategically expand the registry, advance the
science of recruitment and retention of AANHPI participants, and examine the factors
associated with research enrollment decisions among referred registry participants. Our specific
aims include: 1) Examine attitudes toward health research in a diverse cohort of 10,000 newly
recruited AANHPI adults in the US; 2) Elicit perspectives and recommendations from CARE
participants about registry retention, and develop, implement, and evaluate recommended
registry retention strategies. The Lightning Report Method will be used to conduct dynamic
qualitative data analysis and rapid synthesis of the findings to allow rapid comparative analyses
across groups and contexts to derive targeted strategies that are sensitive to the diverse needs
of retaining AANHPI participants; and 3) Optimize CARE registry participants’ inclusion in NIA-
funded and other aging studies and examine factors including study- and participant-level
factors associated with participation in research. These innovative aims will increase and test
the value of the CARE registry and inform the field more broadly on how best to increase
representation of AANHPI groups in research. CARE is well-positioned to complete these aims
and contribute to the growing science of recruitment and retention. This proposed application is
responsive to PAR-22-093 (Research on Current Topics in ADRD) and NOT-AG-21-033 (Notice
of Special Interest: Health Disparities and AD).

## Key facts

- **NIH application ID:** 10740342
- **Project number:** 1R01AG083926-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Joshua Grill
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $3,222,420
- **Award type:** 1
- **Project period:** 2023-08-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10740342

## Citation

> US National Institutes of Health, RePORTER application 10740342, Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0 (1R01AG083926-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10740342. Licensed CC0.

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