# ShEEP Request for Particle Matrix ZetaView

> **NIH VA IS1** · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2023 · —

## Abstract

Extracellular vesicle (EV) research is a fast-moving area of research. Biological nanoparticles
such as EVs, exosomes, viruses, lipids are part of normal homeostasis and now we believe a
major part of pathological conditions. The San Francisco VA was the first in the UCSF community
to purchase a NanoSight nanoparticle tracking system, 8 years ago. The field has moved very
quickly and the new Particle Matrix ZetaView, we believe has replaced the NanoSight technology.
The ZetaView can rapidly characterize particles as to size, particle concentration and surface
charge. It also has the advantage of characterizing particles by fluorescent labelling without any
additives and with a very small sample. The ZetaView has 4 lasers to enable the user to use
different dyes to discriminate different particles and allows the user to quantify colocalization ratios
of biomarkers. This nanoparticle tracking analysis is rapid and user friendly. This basic
characterization of EV particles is essential in any project to use EVs as biomarkers and
treatments. This new machine will attract new users to the field of EVS and facilitate current users
for their funded projects.

## Key facts

- **NIH application ID:** 10741098
- **Project number:** 1IS1BX006328-01
- **Recipient organization:** VETERANS AFFAIRS MED CTR SAN FRANCISCO
- **Principal Investigator:** Lynn PULLIAM
- **Activity code:** IS1 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2023
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2023-03-01 → 2023-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10741098

## Citation

> US National Institutes of Health, RePORTER application 10741098, ShEEP Request for Particle Matrix ZetaView (1IS1BX006328-01). Retrieved via AI Analytics 2026-06-13 from https://api.ai-analytics.org/grant/nih/10741098. Licensed CC0.

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