# C0-Overall:  Fetal Ethanol-induced behavior deficits: Mechanisms, diagnosis and Intervention

> **NIH NIH P50** · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $1,469,412

## Abstract

NMARC is a NIAAA-designated Specialized Alcohol Research P50 Center comprised of teams of preclinical and
clinical scientists with a history of collaborative research interactions, whose expertise and contributions have
synergized the center’s research environment and is facilitating progress towards the achievement of NMARC’s
three strategic objectives. These objectives are to: 1) Advance our understanding of how prenatal alcohol
exposure (PAE) affects basic neurobiological mechanisms resulting in functional brain damage, which can lead
to life-long adverse neurobehavioral consequences. 2) Develop more effective approaches for the diagnosis of
individuals with FASD by establishing more sensitive and clinically reliable biomarkers of PAE that are detectable
earlier in life, are prognostic of functional brain damage, and could predict long-lasting neurobehavioral
consequences in patients with FASD. 3) Develop interventions more effective for PAE-related behavioral deficits.
Better interventions may require combinations of neurobehavioral, educational and/or pharmacotherapeutic
approaches to ameliorate the often subtle, but long-lasting impact of PAE. NMARC’s prevailing philosophy is
that a research center organized to maximize the coordination, communication and synergistic integration across
multiple lines of preclinical and clinical investigation provides the best long-term prospect of achieving significant
progress towards the dual clinical goals of better diagnosis and interventions that are more effective for patients
with FASD. NMARC’s specific aims as an integrated whole during the P50 Phase III will continue to be to: 1)
Accelerate progress on each on NMARC’s three strategic objectives. 2) Catalyze the expansion of NMARC’s
research capacity and capabilities. 3) Enhance our ability to disseminate knowledge about FASD through
seminars, symposia and community outreach activities. 4) Increase the number of undergraduate and graduate
students, fellows and residents training in the FASD research field. This competing renewal contains three
preclinical and one clinical research components, each consisting of teams of investigators whose projects
address one or more of NMARC’s three strategic objectives. Three core components support the research
program: 1) A Pilot Project Core of two two-year projects involving faculty investigators new to FASD research.
2) A Scientific Core supporting production of experimental offspring for preclinical projects and recruitment of
human subjects for the clinical project, as well as data management and statistical support for all NMARC-
affiliated projects. 3) An Administrative Core providing scientific and administrative leadership for the entire
NMARC, along with administrative support and budgetary oversight of all NMARC-related activities. The
Administrative Core and a Steering Committee are also responsible for ensuring progress towards achieving the
Specific Aims of the Center as a whole. Assessment of NMA...

## Key facts

- **NIH application ID:** 10741686
- **Project number:** 2P50AA022534-11
- **Recipient organization:** UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- **Principal Investigator:** Carlos Fernando Valenzuela
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,469,412
- **Award type:** 2
- **Project period:** 2014-08-05 → 2029-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10741686

## Citation

> US National Institutes of Health, RePORTER application 10741686, C0-Overall:  Fetal Ethanol-induced behavior deficits: Mechanisms, diagnosis and Intervention (2P50AA022534-11). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10741686. Licensed CC0.

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