The BRAINS (Broadening the Representation of Academic Investigators in NeuroScience) Program, established in 2011, explicitly addresses the inclusion, retention, and advancement of early career (post Ph.D. to pre-tenure) neuroscientists from historically underrepresented and marginalized groups (URMGs: individuals from marginalized racial and ethnic identities and persons with disabilities). BRAINS has pioneered a unique cohort-based professional development approach that positively impacts participants’ career trajectories, especially in academic neuroscience, by building a community of neuroscience peers1,2, enabling mentoring networks3,4, activating participants’ cultural capital1, and increasing participants’ career self-efficacy5. The success of BRAINS is evident by our findings that 90% of the 144 participants continue to remain in neuroscience careers. Moreover, 50% are currently in tenure track positions, compared to 24% at time of joining BRAINS. With this renewal application, Aim 1 seeks to build on the successes of BRAINS by expanding our program through an increase in the number of the BRAINS community participants, as well as deepening the engagement of all participants with core BRAINS skills and concepts. When compared to other national professional development programs, the BRAINS program stands out in terms of the extent to which BRAINS participants continue to engage deeply with the community long after their first year in the program. In its first decade, evaluation data show that BRAINS programming is a consistent transformational and foundational resource for its participants. Thus, the BRAINS program is uniquely positioned to explore and identify the essential factors that increase retention of neuroscientists from URMGs in academic and nonacademic science careers. Therefore, in Aim 2, we will introduce a new 10-year evaluation instrument to help us to better understand why the program is impactful and what sticks with participants as they progress through their careers. In summary, these Aims will allow BRAINS to expand in terms of participant numbers and in terms of continuing to empower over 200 neuroscientists from URMGs to thrive and advance in their careers. Further, this work will shed new light on the important factors that can improve the long term retention of neuroscientists from URMGs in science careers, which in turn can inform the development of future programs and institutional policies aimed at increasing the retention of URM scientists in biomedical careers.