# Circadian regulation of neocortex

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 2024 · $408,419

## Abstract

Project Summary
Little is known about the mechanisms that determine daily rhythms in rest-activity. We recently
found that cells within the motor cortex can be synchronized to daily cycles of glucocorticoids.
We hypothesize that daily suprachiasmatic nucleus activity and corticosterone secretion entrain
circadian rhythms in cortical neurons and astrocytes to regulate daily patterns of behavior. We
will take advantage of new high-throughput, machine learning and the ability to record and
manipulate gene expression and calcium levels in specific cell types in mice. Combining these
methods with two-color, real-time imaging of gene expression simultaneously in neurons and
astrocytes, we will determine the roles of cortical neurons and glial in distinct daily activities.

## Key facts

- **NIH application ID:** 10746006
- **Project number:** 5R01NS121161-03
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Erik Herzog
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $408,419
- **Award type:** 5
- **Project period:** 2021-12-01 → 2026-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10746006

## Citation

> US National Institutes of Health, RePORTER application 10746006, Circadian regulation of neocortex (5R01NS121161-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10746006. Licensed CC0.

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