# Gene Regulation in Innate Immunity

> **NIH NIH R37** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $490,775

## Abstract

PROJECT SUMMARY (See instructions):
The goal of this project is to understand mechanisms of gene regulation in the innate immune response. 
During the past many years, with support from this grant, we have pioneered work with fundamental 
implications to our understanding of inflammatory responses. During the past 5 years, the funding stability 
provided by this MERIT award, enabled us to significantly expand our field of expertise, which resulted in 
several highly significant and unexpected discoveries, which form the basis of the work proposed over the 
next 5 years of the award. In particular, we documented a totally novel nucleic acid binding protein CNBP 
which directs Th1 immune response in vivo and connected lncRNA biology to innate immunity and the 
inflammatory process. In the proposed extension of this MERIT award we will advance on the foundational 
observations that linked Cnbp as a specific regulator of IL12p40 gene transcription by defining in detail the 
molecular mechanisms of Cnbp-dependent control of c-Rel. We will also explore the cell type specific role 
of Cnbp in controlling Th1 immunity using the T. gondii model. Further, we will explore the contribution of 
Cnbp in control of the IL23-TH17 response. Lastly, we will expand on our studies of lincRNA-Cox2 to 
explore regulation of Cox2 and immune responses in vivo.

## Key facts

- **NIH application ID:** 10746425
- **Project number:** 5R37AI067497-15
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** Katherine A. Fitzgerald
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $490,775
- **Award type:** 5
- **Project period:** 2006-03-01 → 2024-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10746425

## Citation

> US National Institutes of Health, RePORTER application 10746425, Gene Regulation in Innate Immunity (5R37AI067497-15). Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/grant/nih/10746425. Licensed CC0.

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