# Mechanisms of Lymphomagenesis of Skin Resident Gamma Delta T cells

> **NIH NIH R01** · NORTHWESTERN UNIVERSITY · 2024 · $435,192

## Abstract

PROJECT SUMMARY
Primary cutaneous gamma delta T cell lymphomas (PCGDTLs) are a collection of highly aggressive, incurable
non-Hodgkin lymphoma of the skin-homing γδ T cell. Median survival is 31 months. Five-year survival is 19.9%.
Without a fundamental understanding of disease pathophysiology, there has been little progress in the last few
decades. A critical unmet need is to uncover novel therapeutic targets via elucidation of basic disease
mechanisms. Lymphoma phenotypes are determined by a combination of somatic mutations and cell of origin.
To elucidate the genomic, transcriptional, and cellular origins of PCGDTLs, we have assembled a large, multi-
institutional cohort of samples representing diverse clinical phenotypes. By analyzing high-dimensional genomic
and immunological data, we hypothesize that we can identify the molecular basis of this disease. Importantly,
these studies represent a serendipitous opportunity to elucidate the biology of skin-resident gamma delta T cells,
a poorly understood but likely important lymphocyte in human skin.

## Key facts

- **NIH application ID:** 10746459
- **Project number:** 5R01CA260064-03
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Jaehyuk Choi
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $435,192
- **Award type:** 5
- **Project period:** 2021-12-13 → 2026-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10746459

## Citation

> US National Institutes of Health, RePORTER application 10746459, Mechanisms of Lymphomagenesis of Skin Resident Gamma Delta T cells (5R01CA260064-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10746459. Licensed CC0.

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