# Interventions to Reduce Infant Mortality and Morbidity in Low Resource Settings

> **NIH NIH UG1** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2023 · $617,441

## Abstract

Project Summary
This application provides evidence that the Principal and International Principal Investigators
leading the UAB-Zambia team have an established record of major accomplishments in the
Global Network, including the design, implementation, and publication of single site and
common protocol clinical trials and studies that led to major international and national guidelines
and improved care practices. The UAB-Zambia team has access to a stable set of
geographically distinct rural clusters and urban delivery facilities where the team has conducted
research over the last 19 years. The international partner, University Teaching
Hospital/University of Zambia, and a multi-disciplinary team consisting of specialists in
obstetrics, pediatrics, and public health in Lusaka, Zambia have collaborated in research,
training, education, and implementation/scale-up of state-of-the-art research targeted to the
most common causes of maternal and neonatal/infant/child mortality and severe morbidities.
The exceptional organizational capabilities and local support facilitate full participation in all
Global Network trials and studies, including high recruitment and over 99% follow-up rates. The
administrative teams at UAB and Zambia provide all the necessary support for the success of all
grant activities. All Zambian staff members have a record of excellent performance and
accomplishments in the Network, including most working with the team since the first cycle of
the Global Network. The proposed team of investigators have collaborated for over 19 years
and will continue to work with the NICHD and other sites of the Global Network to lead
innovative and impactful randomized trials and observational studies that transform the care of
mothers and infants. The UAB-Zambia team has designed major transformative studies
including the FIRST BREATH, BRAIN-HIT, and A-PLUS trials as well as the Predictive Modeling
for Perinatal Mortality in Resource-Limited Settings database study. The qualifications and
unequivocal commitment of the investigators the Zambian staff, as well as the full endorsement
of the Government of Zambia, University Teaching Hospital (Zambia), University of Zambia, and
the University of Alabama at Birmingham will ensure superior performance if this site is granted
participation in the Network. The long-term objective is to improve local health care systems
with education, training, research, implementation, and sustainability of programs to decrease
preventable maternal and child mortality and morbidities.

## Key facts

- **NIH application ID:** 10746483
- **Project number:** 2UG1HD078437-11
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** WALDEMAR A. CARLO FONT
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $617,441
- **Award type:** 2
- **Project period:** 2013-05-03 → 2030-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10746483

## Citation

> US National Institutes of Health, RePORTER application 10746483, Interventions to Reduce Infant Mortality and Morbidity in Low Resource Settings (2UG1HD078437-11). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10746483. Licensed CC0.

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