# Community Engagement Core

> **NIH NIH U54** · UNIVERSITY OF HAWAII AT MANOA · 2023 · $144,772

## Abstract

ABSTRACT
This proposal for the Community Engagement Core (CEC) for the Pacific Center for Genome
Research (PCGR) has a long-term goal to ensure the Center’s consideration of equity and
ethics in the examination of genetic and other risk factors across the underserved and ethnic
minority groups including Native Hawaiians (NHs), Africans, Latinos, Europeans, and Asians,
served by this proposal. Additionally, the CEC will develop resources to support genetic
education and training for students, medical providers, and the broader community, including
the medically underserved communities identified for investigation. We will work closely with our
Genomic Workforce Development Core and the Administrative Core to build a repository of
resources for use in various formats to support the Center’s training and educational activities.
Additionally, we will hold annual workshops and seminars to build awareness of the implications
of genomic research in partnership with the community-based organizations working with these
underserved groups. The first aim of the CEC is to Provide clinical and community stakeholder
input and oversight for Project 1 objectives to use data from the Population Architecture using
the Genomics and Epidemiology Consortium, the Multi-Ethnic Study of Atherosclerosis, the
Genetic Epidemiology Network of Arteriopathy, INTERVAL, Atherosclerosis Risk in
Communities, UK Biobank, and Framingham Heart Study to develop genetic prediction models
to identify causally relevant biomarkers for risks of multiple diseases across African, Latino,
Asian, European, and NH groups and understand marker-risk factor interaction effects on
disease risks. The second aim is to provide clinical and community stakeholder input and
oversight for Project 2 objectives to characterize the genomic landscape, perform epigenomic
profiling and identify genomic risk factors for lung cancer in NHs by comparing them with the
genomics and epigenomics data from other ethnic groups. The final aim of the CEC is to
support student, stakeholder, and community education and awareness of the U54 PCGR. To
achieve these aims, the CEC will convene Community Advisory Boards to support the
promotion and education about the two U54 PCGR projects among physicians, content experts,
and community stakeholders. The CEC will also develop and implement a regular series of
community seminars and workshops to disseminate U54 PCGR and external genome research
leaders’ scientific findings and identify strategies for implementing risk identification methods in
clinical settings. As a result, the CEC will contribute y to the success of the U54 PCGR projects
and provide an optimal foundation for future genomic research at the University of Hawaii.

## Key facts

- **NIH application ID:** 10749845
- **Project number:** 1U54HG013243-01
- **Recipient organization:** UNIVERSITY OF HAWAII AT MANOA
- **Principal Investigator:** Kevin Darryl Cassel
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $144,772
- **Award type:** 1
- **Project period:** 2023-09-15 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10749845

## Citation

> US National Institutes of Health, RePORTER application 10749845, Community Engagement Core (1U54HG013243-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10749845. Licensed CC0.

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