Project Summary/Abstract Despite lower age-specific rates of stroke in women compared to men, stroke has a disproportionate impact on the lives of women. The objective of this conference is to bring together multidisciplinary experts, and early career and underrepresented investigators to detail the current state of the science related to stroke in women, discuss knowledge gaps in the field, and propose future research initiatives that can be supported by this group and others moving forward. The conference will focus on three inter-related themes relevant to stroke in women: 1) social and economic circumstances of women and men and the impact on stroke, 2) mechanisms of sex differences in stroke as determined by pre-clinical research studies, and 3) increasing enrollment of women in stroke-related randomized clinical trials. The conference will expand on previous collaborations and networking initiated by the multidisciplinary, ad hoc working group on stroke in women -- Prevention and Outcomes in Women Enhancing Stroke Support (PROWESS). The conference has been designed to support junior faculty and individuals from underrepresented groups working in the area of stroke, sex differences, and women, with the goal of assisting them to develop focused hypothesis-driven research relevant to stroke in women. The conference will result in the dissemination of a summary statement and the development of collaborations to advance future research.