Project Summary This proposal seeks partial support for the 2023 Enzymes, Coenzymes, and Metabolic Pathways GRC/GRS. These meetings are scheduled for July 15–16 (GRS) and July 16–21 (GRC) at the Waterville Valley Resort, in Waterville Valley, NH. The “Enzymes” GRC/GRS is the paramount conference for scientists investigating the structure and function of enzymes and their role in metabolism and disease. The long-term goals of this conference are to stimulate communication within the broad research community with interests in the roles of enzymes in life’s essential biological processes. To reach these goals, the GRC has developed a technical program of 36 speakers (28 invited and 8 selected from poster abstracts), and the GRS has assembled a program of 9 speakers (1 invited and 8 chosen from poster abstracts) as well as a Bioscience Careers Panel consisting of ~5 leaders from various backgrounds. These oral presentations will disclose the most recent findings in enzymology, experimental method development, as well as how these are implicated in disease. The GRC Chairs have emphasized that these scholars reflect a diverse and inclusive backgrounds: half of the scheduler speakers are women, and several are from underrepresented groups. We also hope to recruit attendees from a similarly wide expanse of diverse backgrounds. Afternoon poster sessions provide an opportunity for all attendees to share their discoveries with the broader scientific community. Of particular importance is that these poster sessions encourage close interactions among both junior and senior investigators. This proposal has high significance because the “Enzymes” GRC is a pivotal conference for researchers investigating the mechanisms of biochemical reactions and provides a central venue for the exchange of knowledge in this essential health-related field. From a healthcare perspective, this proposal is highly significant due to its focus on the development of new enzyme-targeted drugs. A major outcome of this proposal will be the continued elucidation of how enzymes, co-enzymes, and metabolic pathways contribute to the development of new therapeutics, especially for the treatment of infectious diseases and cancer.