ABSTRACT Support is requested for a Keystone Symposia conference entitled Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade, organized by Drs. Jorge Henao-Mejia, Eran Elinav and Lora Hooper. The conference will be held in Snowbird, Utah from October 8-11, 2023. At different stages of life, interactions between the host microbiota and the immune system play critical roles in protective immune responses against pathogens and determine the efficacy of vaccines and immunotherapies. Moreover, in most tissues of mammalian organisms, alterations in the composition of the host microbiota significantly contribute to chronic inflammatory processes. However, the mechanisms by which the microbiota regulates the immune system in multiple tissues and at different life stages, in the context of health and disease, remains largely undetermined. This conference will bring together leading experts in the field who are currently developing novel approaches in genomics, metagenomics, metabolomics and imaging technologies, to establish the mechanisms by which specific components of the microbiota regulate immune responses in different tissue contexts. In addition, this conference is being held jointly with the Keystone Symposia conference on Circulating Metabolic Intermediates as Fuels and Signals. It is anticipated that this pairing will lead to new scientific collaborations, the development of new technological approaches directed at understanding the underlying mechanisms of microbiota-immune interactions, and the nucleation of academic-industrial interactions that will translate basic mechanistic insights in the field into new therapeutic modalities.