# Methods Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $215,101

## Abstract

ABSTRACT – METHODS CORE
The Methods Core supports the CHIPTS mission by guiding measurement, statistical methods, and
implementation science across the center's aims and initiatives, maximizing innovation and impact. It applies
methods expertise specifically toward assessing influences of mental health, substance use, and social and
structural determinants of health on HIV-associated treatment and prevention outcomes. We respond to an
HIV research environment with an expanding mix of biomedical strategies, including long-acting agents for HIV
prevention and treatment, as well as a growing need to integrate information from multiple data sources (e.g.
mobile-phone-based assessments, electronic health records, laboratory data, administrative and public-use
databases). The push toward implementation science, community-partnered research, and team science
demands development of new methods. The Methods Core also targets measurement and evaluation of
persistent disparities across diverse racial/ethnic and sexual/gender minority populations in advancing HIV
research methodology when conducting investigator-initiated research and service-oriented activities. The
specific aims are (1) Science: To foster and facilitate cutting-edge HIV research by developing and
disseminating innovative technologies and analytic strategies for combination HIV prevention and treatment
research that transcends individual models, including but not limited to implementation science; (2)
Networking: To connect scientists across disciplines and across networks with complementary expertise and
community partners to bi-directionally inform available research tools and identify need for advances in analytic
methodologies; and (3) Capacity building: To recruit, mentor, and support high-caliber investigators with
methods expertise and disseminate innovative methods, assessment tools, and platforms through in-person
and virtual training activities with emphasis to emerging scientists from underrepresented minorities in science.
The Methods Core is guided by a broad causal-inference paradigm to maintain a scientific foundation in all
research activities and in evaluating potential impacts. The Methods Core will prioritize three areas: (a)
Harmonizing evidence across multiple data sources; (b) Statistical methods for complex applied contexts
including management of high-dimensional measurements, of varying data types, of missing data, and of other
complexities in HIV prevention research; (c) Dissemination and implementation science consultations utilizing
participatory approaches, balancing fidelity and adaptation, identifying core elements, modeling decision-
making in intervention adoption, and applying system-analytical tools. In housing the “UCLA Rapid, Rigorous,
Relevant Implementation Science Hub”, the core further expands its capacity to support and guide
implementation science principles and best practices in HIV prevention.

## Key facts

- **NIH application ID:** 10755345
- **Project number:** 5P30MH058107-28
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Sung-Jae Lee
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $215,101
- **Award type:** 5
- **Project period:** 1997-09-30 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10755345

## Citation

> US National Institutes of Health, RePORTER application 10755345, Methods Core (5P30MH058107-28). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10755345. Licensed CC0.

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