# Lipid Peroxidation Analytical Core

> **NIH NIH P01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $221,879

## Abstract

CORE C PROJECT SUMMARY
The overall goal of this program project is to test the contribution of changes in high density lipoprotein (HDL)
function in human disease, specifically atherosclerosis. One of the major hypotheses tested is that the lipid
peroxidation that occurs during various condition that increase the risk for atherosclerosis (e.g. familial
hypercholesterolemia and chronic kidney disease) causes HDL to become modified by reactive lipid
dicarbonyls and that these modifications markedly alter HDL function. This core will provide synthetic versions
of these reactive dicarbonyls to project investigators so that they can test the effects of HDL modification. This
core will also provide synthetic compounds that act as dicarbonyl scavengers and that can be used in both
cultured cells, in animals, and in humans to block the reaction of dicarbonys with proteins and
phosphatidylethanolamine. These scavengers are useful both to test the contribution of these dicarbonyls and
as potential medicinal agents. Finally, this core will measure dicarbonyl adducts on proteins and
phosphatidylethanolamine.
Aim 1: Synthesize IsoLG and other dicarbonyls for testing in cultured cell and animal models.
Aim 2: Synthesize dicarbonyl scavengers for testing in cultured cell and animal models.
Aim 3: Measure the amounts of dicarbonyl modified proteins and phosphatidylethanolamines that are
formed in tissue samples and fluids in animal models and humans with disease.

## Key facts

- **NIH application ID:** 10755709
- **Project number:** 5P01HL116263-09
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** SEAN Stephen DAVIES
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $221,879
- **Award type:** 5
- **Project period:** 2014-06-01 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10755709

## Citation

> US National Institutes of Health, RePORTER application 10755709, Lipid Peroxidation Analytical Core (5P01HL116263-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10755709. Licensed CC0.

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