# Multi-Omics Characterization of Plasmodium Vivax Hypnozoites

> **NIH NIH R01** · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $705,012

## Abstract

Abstract
Plasmodium vivax parasites threaten half of the world’s population and are surprisingly resilient to on-going
malaria elimination efforts, partially due to their ability to remain dormant in the liver as hypnozoites for weeks or
months. Here, we propose to conduct state-of-the-art transcriptomic, epigenomic and lipidomic analyses using
materials collected from non-human primates infected with P. vivax, and in vitro infections of human hepatocytes
with patient-derived P. vivax sporozoites. Our analyses will provide a comprehensive perspective on the
molecular and cellular mechanisms underlying the onset, maintenance and exit of P. vivax dormancy, and well
as on the response of the host, from the infected hepatocytes to the organ- and organism-wide responses. Our
findings will not only provide a better understanding of the fundamental processes underlying the fate and
development of liver-stage P. vivax parasites but will also provide a solid foundation to develop better malaria
vaccines and therapies against this important but understudied human pathogen.

## Key facts

- **NIH application ID:** 10757036
- **Project number:** 5R01AI172827-02
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** David Serre
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $705,012
- **Award type:** 5
- **Project period:** 2022-12-22 → 2027-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10757036

## Citation

> US National Institutes of Health, RePORTER application 10757036, Multi-Omics Characterization of Plasmodium Vivax Hypnozoites (5R01AI172827-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10757036. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*