# Cardiovascular Diseases among Patients with Cancer and Patients living with HIV

> **NIH NIH K24** · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $123,109

## Abstract

Project Summary/Abstract: Tomas Neilan MD MPH is a clinically-active cardiologist in the Division of
Cardiology and Cardiovascular Imaging at Massachusetts General Hospital and an Associate Professor of
Medicine at Harvard Medical School. Over the last 10 years, Dr. Neilan’s research has focused on applying
advanced imaging to two complementary areas, the cardiovascular toxicities associated with cancer therapies
and heart failure among persons with HIV. Dr. Neilan’s extensive mentoring experience, publication and
funding record, together with his current and planned research support, demonstrate his commitment and
passion for POR and provide an excellent foundation to accomplish the goals and objectives of the K24 Award.
The specific aims addressing the purpose of the K24 Award are: 1) To enable Dr. Neilan to dedicate 25% of
his time to mentor junior clinical investigators based on already NIH funded projects; 2) To mentor junior
clinical investigators from the T-32 program and the pool of residents, fellows, and junior faculty in Cardiology
and Radiology with the goal to develop them into clinical researchers who can successfully compete for peer
reviewed grants; and 3) To enable Dr. Neilan to consolidate a POR that combines innovative translational,
clinical, and outcomes research in cardiovascular imaging and that provides an ideal environment to develop
future leaders in clinical research. Dr. Neilan’s current leadership roles align well with this proposal. He is the
Co-Director of the Cardiac MR CT PET Program, a clinical research program in cardiovascular imaging
supported by the Division of Cardiology and the Department of Radiology, the Associate Director of the MGH
T32 training grant in cardiovascular imaging, and the Director of the Cardio-Oncology Program in the Division
of Cardiology. In addition to his roles, Dr. Neilan also has an unreserved commitment from the leadership of
both Cardiology and Radiology providing a foundation that is ideal to successfully mentor junior clinical
investigators and fulfill the purpose of the Award. The specific research aims of this grant stem from a
significant body of work accomplished over the past few years and are all based on on-going NIH funded
projects, except Aim 4 which is new research specifically supported by this grant:
1) STOP-CA – Testing in a randomized multicenter clinical trial the effect of statins on the reduction in left
ventricular ejection fraction after anthracycline-based chemotherapy, 2) REPRIEVE-MR – Testing in a
randomized multicenter clinical trial whether statins reduce myocardial fibrosis, myocardial steatosis and
preserve cardiac function among persons living with HIV, 3) STOP-CA Fibrosis – where we apply novel MRI-
based imaging techniques to provide insight into the role of myocardial fibrosis in the development of
anthracycline-induced cardiotoxicity, and test the effect of statins on myocardial fibrosis after anthracyclines,
and 4) Expanding our international regis...

## Key facts

- **NIH application ID:** 10757376
- **Project number:** 5K24HL150238-05
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Tomas G Neilan
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $123,109
- **Award type:** 5
- **Project period:** 2020-01-02 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10757376

## Citation

> US National Institutes of Health, RePORTER application 10757376, Cardiovascular Diseases among Patients with Cancer and Patients living with HIV (5K24HL150238-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10757376. Licensed CC0.

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