Project Summary – Administrative Core The goal of the CORT is to elucidate mechanisms of action of osteoporosis anabolic therapies, and to understand why they stop working over time. In doing so, the CORT will accelerate translation knowledge to improve our understanding of osteoporosis pathobiology. To achieve this goal, the overall focus of the CORT is to define the cellular and molecular mechanisms of action of currently-used osteoporosis anabolic agents in humans. A highly-collaborative, multi- disciplinary, international network of investigators based at several Harvard Medical School- based institutions and Imperial College London have come together to tackle this challenge. The goal of the Administrative Core is to provide administrative support for all aspects of the CORT and its scientific mission. To achieve this goal, three specific aims are proposed. First, the Administrative Core will support the scientific goals of the CORT via coordinating management across projects, supporting a pilot award program, supporting patient recruitment efforts, and facilitating scientific and regulatory reporting. Second, the Administrative Core will provide infrastructure and timely support to ‘unburden’ CORT investigators by coordinating teleconferencing, meeting planning, travel arrangements, and performing post-award grants management. Third, the Administrative Core will function as a ‘hub’ for engagement and dissemination of CORT scientific activities with the broader academic skeletal biology and osteoporosis research communities. These efforts will rely on integration with existing dissemination networks for translational science, a Visiting Professor series, and developing a robust series of platforms to publicize the CORT mission. The Administrative Core leadership structure will involve a director and associate director with appropriate expertise in fundamental, translational, and clinical skeletal biology research, with support from an appropriately-selected External Advisory Committee panel. In sum, the Administrative Core represent an integral component needed for the success of this collaborative, multi-disciplinary, inter-institutional translational research program.