# Transcriptional Regulation of Lung Cancer Identity

> **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $365,750

## Abstract

Project Summary
Lung adenocarcinoma, the most common cause of cancer death worldwide, exhibits substantial heterogeneity
in cellular identity, or differentiation state. In this disease, cancer cell identity correlates with critical clinical
parameters, including patient prognosis, intrinsic sensitivity to therapy, and acquisition of drug resistance.
Thus, there is an unmet need to obtain a comprehensive understanding of mechanisms controlling LUAD
identity. A major rationale for this proposal is that a mechanistic understanding of the complex interplay
between lineage specifiers and oncogenic signaling pathways in LUAD must be achieved before such
therapeutic strategies can be developed. The immediate goal of this application is to test the central hypothesis
that lineage specifiers and oncogenic signaling pathways coordinately modulate LUAD identity and growth.
This hypothesis will be tested in the following specific aims via an integrative experimental approach employing
genetically engineered mouse models (GEMMs), organoid cultures, human PDX models/cell lines and clinically
relevant pathway inhibitors: (1) Identify mechanisms by which FoxA1/2 promote tumorigenesis and activate a
mixed-lineage state in NKX2-1-positive lung adenocarcinoma. (2) Identify mechanisms by which oncogenic
signaling pathways regulate identity in NKX2-1-negative lung adenocarcinoma.

## Key facts

- **NIH application ID:** 10758277
- **Project number:** 5R01CA212415-07
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Eric Lee Snyder
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $365,750
- **Award type:** 5
- **Project period:** 2017-07-01 → 2027-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10758277

## Citation

> US National Institutes of Health, RePORTER application 10758277, Transcriptional Regulation of Lung Cancer Identity (5R01CA212415-07). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10758277. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*