Project Summary The administrative core will provide a management plan to coordinate the whole SYBIL consortium by 1) establishing an organizational structure centered on an Executive Committee responsible for monitoring overall program progress and making decisions on staffing plans, allocation of resources, core usage and other policies; 2) coordinating bi-weekly conference calls and organizing site visits between the project and core leads, selected key personnel, the Scientific Advisory Group and NIAID; 3) assisting the investigators of this consortium in reagents and data sharing, manuscript preparation, public release of data and submission of semi-annual and annual progress reports to NIAID; and 4) providing training opportunities in systems biology for the infectious disease scientist. The Core Director has expertise in the coordination of program projects and big consortiums, as he is the Director of one of the NIAID Centers of Excellence for Influenza Research and Response (CEIRR). Moreover, he has been successfully coordinating the previous U19 consortium, “FluOMICS, The Next Generation.” The Core Co-Director is in charge of the training program to be implemented in years 2 to 5 and he has past experience in organizing training for students in systems biology approaches.