# Regional Prospective Observational Research in Tuberculosis (RePORT) – Brazil Network

> **NIH NIH U01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $1,000,000

## Abstract

PROJECT SUMMARY
Brazil has the highest tuberculosis (TB) burden in the Western Hemisphere, and among the highest in the
world. Advances in TB diagnosis, treatment, and prevention are necessary to improve the incidence, morbidity,
and mortality of TB in Brazil, and globally. Regional Prospective Observational Research in TB (RePORT)-
Brazil was initiated by our group in 2013, and enrolled 1,188 pulmonary TB patients and 1,930 of their close
contacts in Phase 1. Clinical data and stored biorepository specimens have facilitated studies of predictors of
TB and TB/HIV treatment outcomes, predictors of M. tuberculosis (Mtb) infection and progression to TB
disease and incipient TB, TB-diabetes, drug-resistant TB, TB diagnostics, and Mtb transmission. Strong
collaborations have been established with investigators in Brazil and the United States, as well as other
RePORT networks (e.g., South Africa and India), the Caribbean Central America South America network for
HIV epidemiology (CCASAnet) and its TB Sentinel Research Network (TB-SRN), which is part of the
International epidemiologic Databases to Evaluate AIDS (IeDEA) network. In Phase 2 of RePORT-Brazil we
will utilize the rich, high-quality clinical, genomic, and transcriptomic data generated in Phase 1, together with
new participant enrollment, to extend our understanding of TB epidemiology and pathogenesis, and improve
the diagnosis, treatment, and prevention of TB. This will be accomplished through three Specific Aims: 1) Gain
insights that improve TB diagnosis, treatment, and outcomes. This will include external validation utilizing the
TB case registry in Brazil (SINAN; the Brazilian National System of Diseases Notification), and other Brazilian
registries as appropriate; 2) Improve our understanding of Mtb transmission and infection, including latent,
incipient, and sub-clinical disease; predictors of progression to TB, and protection against TB; and 3) Support
and develop the next generation of TB scientists, and enhance the scope and collaboration of RePORT-Brazil.
For Aim 3, we will fund Fellowships in TB Science, focusing on Brazilian investigators. This will include two
Early Career Development Fellowships per year, for pilot projects that support Brazil-US partnerships, and
generate preliminary data for subsequent grant funding; and two Post-Doctoral Fellowships per year. Both
categories of support will be for studies that utilize RePORT-Brazil data and/or specimens; proposals that also
include data and specimens from other TB cohorts will be encouraged. The three Aims will facilitate further
growth and strengthening of RePORT-Brazil, and generate insights that improve the diagnosis, treatment, and
prevention of TB in Brazil.

## Key facts

- **NIH application ID:** 10758619
- **Project number:** 5U01AI172064-02
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** BRUNO DE BEZERRIL ANDRADE
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,000,000
- **Award type:** 5
- **Project period:** 2023-01-02 → 2027-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10758619

## Citation

> US National Institutes of Health, RePORTER application 10758619, Regional Prospective Observational Research in Tuberculosis (RePORT) – Brazil Network (5U01AI172064-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10758619. Licensed CC0.

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