Project Summary - Technology Core The Center for Viral Systems Biology (CViSB) requires the generation of large, multivariate datasets, many of which necessitate modifying existing experimental and computational approaches or creating novel methods. The Technology Core’s primary responsibility is providing state-of-the-art, high throughput omics and functional services to support CViSB’s Projects. We will leverage our considerable expertise and experience with these techniques and, to ensure that we maintain our position as a cutting-edge experimental facility, we will identify, develop and adapt emerging technologies with the potential to further CViSBs scientific aims. We will then translate these innovative experimental approaches into standardized protocols and methods that are suitable for distribution and reuse. To accomplish these objectives and support the overall mission of CViSB, we have the following four aims: (1) Evaluate, develop, and improve experimental methods and analysis tools for multi-omics analysis of host adaptive immune function; (2) Develop and improve cost-effective next-generation methods for large-scale virus sequencing; (3) Provide cutting-edge sequencing and omics services to support the data generation needs of CViSB’s Projects and investigators; and (4) Create and distribute open access standard operating procedures, protocols, and methods.