# An enzyme-based assay for the detection of acetaldehyde-protein adducts

> **NIH NIH R43** · REVEL PHARMACEUTICALS INC. · 2023 · $272,137

## Abstract

ABSTRACT
Chronic alcohol consumption is a significant issue worldwide which can lead to addiction and damage
throughout the body. The first step in alcohol metabolism is its conversion into acetaldehyde, which is a highly
reactive and toxic molecule. The formation of acetaldehyde adducts with protein and DNA is a primary
mechanism of ethanol toxicity. Acetaldehyde adducts are a direct biomarker for alcohol abuse. We intend to
develop a facile and rapid enzyme-based assay for measuring acetaldehyde-protein adducts to assess alcohol
use and alcohol-related health consequences.

## Key facts

- **NIH application ID:** 10760201
- **Project number:** 1R43AA030937-01A1
- **Recipient organization:** REVEL PHARMACEUTICALS INC.
- **Principal Investigator:** Kevin K Desai
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $272,137
- **Award type:** 1
- **Project period:** 2023-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10760201

## Citation

> US National Institutes of Health, RePORTER application 10760201, An enzyme-based assay for the detection of acetaldehyde-protein adducts (1R43AA030937-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10760201. Licensed CC0.

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