# Rat Genome Database

> **NIH NIH R01** · MEDICAL COLLEGE OF WISCONSIN · 2024 · $1,902,667

## Abstract

Project Summary
The Rat Genome Database (RGD) has evolved substantially from a catalog of rat genetic markers, maps, and
genes to a comprehensive resource with multiple genomic data types, extensive disease and phenotype
annotations, and tools to effectively mine, analyze and visualize the available data. The goal of RGD is to enable
investigators in their hypothesis-driven research. Leveraging its robust and flexible infrastructure, RGD has
added data from human and other important human disease model organisms to enhance its translational
aspect. RGD is also one of the founding members of the Alliance of Genome Resources (Alliance), a consortium
of the major model organism databases focused on harmonizing and presenting cross-species information.
Since 2019, there has been an exciting reinvigoration in the rat genomics community and research. Through
collaboration with the Wellcome Sanger Institute, a new and vastly improved rat reference genome (mRatBN7.2)
has been generated and released, and RGD joined the Genome Reference Consortium (GRC) to curate it.
Several complementary NIH-funded projects focused on generating whole genome, transcriptome, and
epigenome sequencing datasets are underway in numerous rat strains representing human disease models;
several strains, including key models of heart, lung, blood and sleep disorders will have strain-specific, muli-omic
data and de novo genome assemblies. RGD has the unique opportunity to be the center of data integration for
these new, unique datasets, the overall theme of this renewal. To continue increasing the value of RGD and
build on the investments made by the NIH and other international funding bodies in rat research, we will develop
an extensive ecosystem for integration of multi-omics and biological data in the rat as a model of common human
complex disease and create a comprehensive comparative species platform to predict precision preclinical
human disease models for further study by research community.

## Key facts

- **NIH application ID:** 10762418
- **Project number:** 5R01HL064541-25
- **Recipient organization:** MEDICAL COLLEGE OF WISCONSIN
- **Principal Investigator:** ANNE E. KWITEK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,902,667
- **Award type:** 5
- **Project period:** 1999-09-30 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10762418

## Citation

> US National Institutes of Health, RePORTER application 10762418, Rat Genome Database (5R01HL064541-25). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10762418. Licensed CC0.

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