# Gainesville Brain Rehabilitation Research Center (BRRC)

> **NIH VA I50** · VETERANS HEALTH ADMINISTRATION · 2024 · —

## Abstract

Cognitive, motor, and mental health consequences of central nervous system are debilitating conditions that
impair the quality of life and community reintegration of many Veterans. These outcomes occur as the result of
damage to neural networks, and restoration of function from such damage is the ultimate goal of
neurorehabilitation. The brain has a remarkable ability to grow new neuronal connections and recover from
injury if it is exposed to appropriate experiences. The long-range strategic plan of the Brain Rehabilitation
Research Center (BRRC) is to harness mechanisms of experience-dependent neuroplasticity and neural
network reorganization to develop, test, and implement rehabilitative treatments for cognitive, motor, and
emotional-neuropsychiatric disability in Veteran survivors of traumatic brain injury (TBI), spinal cord injury (SCI)
and stroke. Treatment efficacy requires proper engagement of restorative and compensatory brain
mechanisms. For example, the BRRC seeks to develop behavioral interventions that specifically engage
impaired neural networks, in some cases with augmentation from non-invasive neuromodulatory adjuvants.
Treatment efficacy also requires minimizing the presence of factors that interfere with neuroplastic changes.
For example, the BRRC seeks to counteract injury-related problems such as neuroinflammatory and
neurotoxic effects with pharmacological interventions, as well as to mitigate the compounding effects of
advancing age and/or poor systemic health. The BRRC’s research portfolio consists of rigorous preclinical
(animal) and clinical (human) investigations that drive the development of treatments that not only potentiate
positive neuroplastic change through rehabilitation, but also mitigate factors that deter the brain’s ability to
repair and recover after injury. Further, the BRRC aims to increase the accessibility of treatments, including
through teletherapy and at-home interventions. The BRRC is comprised of a multi-disciplinary team of
scientists in a highly collaborative environment that is fertile for translation of basic science discoveries to the
real-life rehabilitation of Veterans with injury-related disabilities. The Center organization reflects three primary
research initiatives: Cognition/Emotion, Motor Function, and Rehabilitation Neuroscience, supported by an
Administrative Core, a Neuroimaging and Biomarker Measurement Core, and a Human Motor Performance
Measurement Core. The Center’s research has a mechanistic focus, is increasingly trans-disciplinary and
features projects that cut across initiatives and cores. Its Neuroimaging and Biomarker core broadly supports
current investigations by providing infrastructure for acquisition and analysis of neuroimaging and biomarkers
of injury, disability and rehabilitation-related neuroplastic change. The BRRC plays an important role in
national brain injury consortium projects, furthering both clinical and basic science. The BRRC, and the
Veterans it serves...

## Key facts

- **NIH application ID:** 10763611
- **Project number:** 2I50RX003000-06
- **Recipient organization:** VETERANS HEALTH ADMINISTRATION
- **Principal Investigator:** PRODIP K. BOSE
- **Activity code:** I50 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2024
- **Award amount:** —
- **Award type:** 2
- **Project period:** 2019-10-01 → 2029-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10763611

## Citation

> US National Institutes of Health, RePORTER application 10763611, Gainesville Brain Rehabilitation Research Center (BRRC) (2I50RX003000-06). Retrieved via AI Analytics 2026-06-29 from https://api.ai-analytics.org/grant/nih/10763611. Licensed CC0.

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