# Learning from Remission and Relapse in SLE

> **NIH NIH P01** · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2024 · $2,902,477

## Abstract

Abstract – Overview
This program project is an exploration of patients with Systemic Lupus Erythematosus who are in long term
clinical remission on no corticosteroid or immunosuppressive medication.
We will study blood immune cells at the single cell level exploring distribution of cellular subsets and
transcriptional, epigenetic and proteomic profiles, as well as the repertoire of naive and memory B cells
reactive with nuclear antigens.
We will explore brain function in these patients to determine if there is ongoing inflammation in the central
nervous system in some patients despite a lack of inflammation in the periphery.
Given the now recognized interplay of the immune system and the brain, we will seek correlations between
immune cell profile and brain function.
As approximately 25% of patients in remission can be expected to relapse over 5 years, we will seek predictors
of relapse.
These studies should teach us about patient heterogeneity, novel states of immune or brain homeostasis, and
predictors of sustained remission or flare.

## Key facts

- **NIH application ID:** 10763686
- **Project number:** 1P01AI172523-01A1
- **Recipient organization:** FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Betty Diamond
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $2,902,477
- **Award type:** 1
- **Project period:** 2024-05-09 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10763686

## Citation

> US National Institutes of Health, RePORTER application 10763686, Learning from Remission and Relapse in SLE (1P01AI172523-01A1). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10763686. Licensed CC0.

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