# Project 1: Multiplexed multimodal single-cell genomic profiling of SLE in remission

> **NIH NIH P01** · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2024 · $1,118,021

## Abstract

Abstract – Project 1
This project will identify the immune states present in 250 SLE patients in long-term drug free
remission (+/- hydroxychloroquine) by analyzing 1) blood for composition of immune cells, 2) the
transcriptional epigenetic and proteomic profile of blood immune cells at the single cell level,
and 3) determining the repertoire of B cells in blood that react with nuclear antigens. The data
will be analyzed in comparison to 60 active SLE patients and 60 healthy controls and will
provide insight into the heterogeneity of immune profiles in patients in remission and the
homeostatic mechanisms to sustain remission. As 25% will likely relapse over 5 years, the
studies may also identify predictors of relapse.

## Key facts

- **NIH application ID:** 10763690
- **Project number:** 1P01AI172523-01A1
- **Recipient organization:** FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Chun Jimmie Ye
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,118,021
- **Award type:** 1
- **Project period:** 2024-05-09 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10763690

## Citation

> US National Institutes of Health, RePORTER application 10763690, Project 1: Multiplexed multimodal single-cell genomic profiling of SLE in remission (1P01AI172523-01A1). Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/grant/nih/10763690. Licensed CC0.

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