# Processivity and Catalytic Mechanism of Aldosterone Synthase

> **NIH NIH F31** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $19,986

## Abstract

Abstract
The finely tuned production of aldosterone controls blood pressure by regulating water and sodium retention.
The overproduction of aldosterone, however, leads to primary aldosteronism, the major form of secondary
hypertension. This mineralocorticoid hormone is produced by cytochrome P450 11B2 (CYP11B2), also known
as aldosterone synthase. While lowering aldosterone levels through inhibition of CYP11B2 has been established
as a potential therapeutic approach, a few challenges are associated with this tactic. For example, CYP11B2
shares a 93% sequence identity with the cortisol-producing P450 11B1 (CYP11B1). Despite the similarities
between CYP11B1 and CYP11B2, there exist key functional and structural differences. Overall, this research
aims to understand how these subtle differences contribute to the catalytic function of these enzymes in order to
aid drug development.

## Key facts

- **NIH application ID:** 10763821
- **Project number:** 5F31GM149006-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Juan Jose Valentin-Goyco
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $19,986
- **Award type:** 5
- **Project period:** 2023-01-05 → 2024-05-02

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10763821

## Citation

> US National Institutes of Health, RePORTER application 10763821, Processivity and Catalytic Mechanism of Aldosterone Synthase (5F31GM149006-02). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10763821. Licensed CC0.

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