# Integrating complementary learning principles in aphasia rehabilitation via adaptive modeling

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $581,600

## Abstract

Aphasia is a language disorder commonly caused by stroke and other acquired brain injuries that affects over
two million people in the US and has a large negative effect on quality of life. Anomia (i.e., word-finding
difficulty) is a primary frustration for people with aphasia, and naming treatments for anomia are both widely
researched and commonly used in clinical practice. For naming treatments to make a meaningful impact on the
lives of people with aphasia, they must produce durable gains in word-finding which generalize beyond the
treatment context. However, most theoretically-motivated naming treatment research fails to address the long-
term retention of trained words and their generalization to connected speech, limiting their clinical impact.
 Prevailing learning theory suggests that “desirable difficulty” improves treatment retention and
generalization. The current proposal therefore seeks to improve the durability and context generalization of
computer-based naming treatment by incorporating model-based algorithms to adaptively maintain desirable
difficulty. We will test two distinct models in parallel clinical trials. Our central premise is that these models will
facilitate a balance between what have historically been framed as contrasting learning approaches: errorless
learning vs. effortful retrieval (Study 1) and massed vs. distributed practice (Study 2). Instead, our models will
integrate these approaches by replacing extreme static contrasts with continuous task components which can
be adaptively modified based on ongoing patient performance. Study 1 will adaptively balance effort and
accuracy using speeded naming deadlines based on a model we have developed which characterizes
individuals’ speed-accuracy tradeoffs in picture naming over time. Study 2 will manipulate trial spacing using
an adaptive scheduling and memory decay model built into widely available, open-source flashcard software.
 In both studies, we predict that when compared to matched traditional non-adaptive treatment
conditions, our adaptive conditions will produce more successful retention of trained words 3 and 6 months
post-treatment on naming probes (Aims 1a, 2a), and better context generalization to connected speech when
tested on complex scene descriptions containing untrained exemplars of trained words (Aims 1b, 2b). We also
predict that adaptive trial spacing in Study 2 will successfully train many more words than is possible in current
standard care. In addition, data generated in Studies 1 and 2 will be used to develop the next generation of
adaptive timing models (Aims 1c and 2c), spurring future innovations in personalized medicine.
Successful clinical trial outcomes will demonstrate that adaptive computer-based naming treatments provide a
novel way to produce large, durable, and generalizable treatment gains, and positive Study 2 findings could be
immediately implemented in clinical practice at scale using free open-source software. Successful model...

## Key facts

- **NIH application ID:** 10763872
- **Project number:** 5R01DC019325-03
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** William Streicher Evans
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $581,600
- **Award type:** 5
- **Project period:** 2022-02-15 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10763872

## Citation

> US National Institutes of Health, RePORTER application 10763872, Integrating complementary learning principles in aphasia rehabilitation via adaptive modeling (5R01DC019325-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10763872. Licensed CC0.

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