# The Mutant Mouse Resource and Research Center at The Jackson Laboratory

> **NIH NIH U42** · JACKSON LABORATORY · 2024 · $1,287,241

## Abstract

ABSTRACT/PROJECT SUMMARY
This application proposes a renewal of the Mouse Mutant Resource and Research Center (MMRRC) at The
Jackson Laboratory. Highly sophisticated genome engineering technologies, a well-characterized genome,
mammalian physiology and economical husbandry requirements make laboratory mice the mainstay of
biomedical research on disease mechanism and for disease modeling. The NIH has recognized that the
potential impact of genetically engineered mice for biomedical research cannot be fully realized without a
centralized effort to identify, archive, evaluate, characterize, and distribute valuable strains of mice to qualified
biomedical researchers. The MMRRC provides this centralized repository function. With over 80 years of
mouse genetics and mouse resource experience, The Jackson Laboratory joined the MMRRC in 2009 and
since has been a key member of the consortium. This proposal requests on-going support for The Jackson
Laboratory as one of the four MMRRC core repositories. As a member of the MMRRC consortium, the Jackson
Laboratory will contribute to the development and improvement of consortium wide standard operating
procedures. The MMRRC at JAX will follow these mutually agreed upon standard operating procedures to fulfill
the goals importation, archiving (through cryopreservation of sperm and/or embryos) and distribution of
biomedically important strains of mice and related materials. The MMRRC at JAX also provides related
services on a fee for service basis and conducts high risk high return research and model development
projects that fit within the overall goals of the consortium.

## Key facts

- **NIH application ID:** 10764206
- **Project number:** 5U42OD010921-15
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** Cathleen M Lutz
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,287,241
- **Award type:** 5
- **Project period:** 2010-01-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10764206

## Citation

> US National Institutes of Health, RePORTER application 10764206, The Mutant Mouse Resource and Research Center at The Jackson Laboratory (5U42OD010921-15). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10764206. Licensed CC0.

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